Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Use Caution/Monitor. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Modify Therapy/Monitor Closely. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. This drug is available at the lowest co-pay. You may need extra iron because of blood loss during kidney dialysis. 1. All Rights Reserved. The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. Shirley, NY: American Regent, Inc.; 9/2020. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. In the text below the tool there is more information on how the iron deficit is calculated. Anemias. Avoid or Use Alternate Drug. For iron maintenance treatment, administer Venofer, (2 years of age or older) with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment. Consult your pharmacist or local waste disposal company. Hollands J, Foote E, Rodriguez A. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. vitamin E decreases levels of iron sucrose by increasing hepatic clearance. Discuss the risks and benefits with your doctor.This medication passes into breast milk. 1995 Mar-Apr;11(2):163-8. Use Caution/Monitor. Normal haemoglobin values are gender specific: for males from 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and females from 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). Avoid or Use Alternate Drug. Use Caution/Monitor. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Discard unused portion. Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. This site complies with the HONcode standard for trust- worthy health information: verify here. In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . 1974 Jun;31(6):592-5. There are physiological variation in iron reserves such as the decrease during menstruation period. Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Diagnosis and management of iron deficiency anaemia: a clinical update. This topic . INFED- iron dextran injection [Package insert], Hemoglobin iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) Note: Hbg (current hemoglobin level) units: (g/dL) Alternatively: Volume of product required (mL) = [weight (kg) x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Each mL contains 20 mg of elemental iron. Your list will be saved and can be edited at any time. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Intravenous therapy is preferred for urgent intervention and when oral iron cannot be absorbed or the patient suffers from chronic renal impairment. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Applies only to oral form of both agents. Applies only to oral form of both agents. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. iron sucrose decreases levels of manganese by inhibition of GI absorption. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Deferoxamine chelates iron. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. FOR PATIENTS WEIGHING 50 kg OR MORE: Administer 1000 mg of Monoferric by intravenous infusion 20 minutes as a single dose 1. Applies only to oral form of both agents. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Treatment of anemia due to iron deficiency. If no signs or symptoms of anaphylactic-type reactions follow the test dose, administer the full therapeutic INFeD dose. Use Caution/Monitor. Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Use Caution/Monitor. Parenteral iron supplementation. Avoid or Use Alternate Drug. Applies only to oral form of both agents. didanosine will decrease the level or effect of iron sucrose by increasing gastric pH. Separate by at least 4 hours. Serious - Use Alternative (1)iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Each mL contains 20 mg of elemental iron. 1) Ganzoni AM. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Intravenous therapy is usually recommended in case of contraindications to oral iron, comorbidities that prevent absorption, chronic renal impairment or iron replacement needs to be rapid. *Repeat dose if iron deficiency anemia reoccurs. Administer a test INFeD dose prior to the first therapeutic dose. Applies only to oral form of both agents. iron sucrose, captopril. Use Caution/Monitor. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. Sodium ferric gluconate complex injection [ Ferrlecit ] [package insert] - Elemental iron: 12.5 mg/mL (5 mL). Schweiz Med Wochenschr; 100(7):301-3. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Separate dosing of tetracyclines from these products. Applies only to oral form of both agents. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. 10th ed. Applies only to oral form of both agents. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Venofer treatment may be repeated if necessary. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy. Applies only to oral form of both agents. Anemia; 2015: 763576. Your doctor will do laboratory tests to monitor your response. however iron sucrose requires multiple small intermittent doses over days to weeks. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Most Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Minor/Significance Unknown. In case a pediatric patient with a weight below 35 kg is assessed, iron stores are calculated as 15 mg iron for each kg. Pregnancy: Risk Summary-Clinical Considerations. Individual plans may vary Do Not Copy, Distribute or otherwise Disseminate without express permission. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Consult your doctor before breast-feeding. Kumpf VJ. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Individual doses of 2 mL or less may be given on a daily basis until the calculated total amount required has been reached. Applies only to oral form of both agents. LBW = Lean body weight in kg. Venofer treatment may be repeated if iron deficiency reoccurs. iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Minor/Significance Unknown. Pediatric Patients (2 Years of Age and Older). Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Interaction only with oral iron administration. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Koch TA, Myers J, Goodnough LT. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. The factor 2.4 comes about from the calculation that the total iron content of hemoglobin is 0.34%, the blood volume accounts for 7% . In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. The iron deficit estimation is based on the Ganzoni formula: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. Applies only to oral form of both agents. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Reactions have occurred following the first dose or subsequent doses of Venofer. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). and formulary information changes. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. provider for the most current information. This website also contains material copyrighted by 3rd parties. Anemia; 2015: 763576. Venofer (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)- . No additional iron to replenish stores. Applies only to oral form of both agents. Use Caution/Monitor. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Manufacturer advises for slow intravenous injection ( Venofer ), give undiluted at a rate of 1 mL/minute; do not exceed 10 mL (200 mg iron) per injection. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. Avoid or Use Alternate Drug. Jacobs P, Dommisse J. This drug is available at a higher level co-pay. We'll do this entirely for free, as long as the calculator has applications for women's health. Avoid or Use Alternate Drug. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. By using this form you agree with the storage and handling of your data by this website. Although the original formula requires the weight in kilograms, values input in lbs are transformed. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. Administer on 5 different occasions over a 14 day period. Minor/Significance Unknown. In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Brand name: Venofer Drug class: Iron Preparations Chemical name: iron saccharate CAS number: 8047-67-4 Medically reviewed by Drugs.com on Oct 25, 2022. This site contains information for licensed healthcare professionals in the United States. Use Caution/Monitor. Each costs about $0.46 to $0.55 per mg of iron. Where C= concentration of Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. Calculation of Dosage of Nefrofer Total Iron Deficit (mg) Nefrofer (ml) = 20mg/ml Total Iron Deficit (mg) = Body weight (kg) x (Target Hb - Actual Hb) [g/l] x 0.24* + Depot Iron . Applies only to oral form of both agents. Either decreases levels of the other by inhibition of GI absorption. 3. Applies only to oral form of both agents. Contraindicated. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Use Caution/Monitor. Deferoxamine chelates iron. Minor/Significance Unknown. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Written by ASHP. Human studies not conducted. Anemia. This site complies with the HONcode standard for trust- worthy health information: verify here. If we don't have the calculator you need then tell us the details and we'll make it for you.