microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. It is a white, free-flowing powder. *r_ *?~4$ &0Y# . Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Well-recognized product that can do it all. endstream Find answers in our support articles. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). : 9004-34-6 Date Approved: 01/31/2008 . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. In 1964 FMC, Corporation . MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Combines good flow and high compactibility. Molecular weight: Not Applicable 1.5. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0 endstream endobj 524 0 obj 458 endobj 525 0 obj << /Filter /FlateDecode /Length 524 0 R >> stream Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Safety Data Sheet (SDS) Viewer. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Document(s): certificate data msds. These include amphiphilicity, a higher degree of crystallinity, surface area, higher hydration properties, and morphology. Explore how you can develop your career and bring your creative ideas to life at IFF. Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. Micro Crystalline Cellulose. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Learn about FMC's differentiated biologically-based crop solutions. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. endobj CAS #: 9004-34-6 . Doses up to 30 g per day appear to be . Hi, let us know if you have any questions as you visit our website. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . %PDF-1.4 Material Safety Data Sheet TALSTAR S INSECTICIDE Version 1 Page 1 / 8 SDS # : 6320-A This MSDS has been prepared to meet U.S. OSHA Hazard Communication Standard 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS) requirements. To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. Wu, K. Zuurman, H.W. gwf;J(e0o|1p{R~P^);ao!%{0KD7. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. 1 0 obj Regulatory Information CAS 9004-34-6, pH 5 - 7.5. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Safety Data Sheet for Cellulose microcrystalline 102331. No. Looking for FMC'searnings news? q9;v80q>jZ PDF (2.77 mb) 2021 FMC Sustainability Report. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Avicel Microcrystalline Cellulose: Chemical Identifiers. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). All Rights Reserved. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. HMo@9, U Q!R/1*;` The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. PDF (4.11 mb) Footer menu 1. Microcrystalline Cellulose / Avicel PH-102. 4. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. /MediaBox [0 0 612 792] Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . cas:9000-11-7 msds Carboxymethyl cellulose. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Your file is uploaded and ready to be published. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. Have an order or account question? It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. } !1AQa"q2#BR$3br /Resources 2 0 R In extrusion-spheronisation, it is the excipient of choice. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. MSDS Ref. }o]X4]. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Microcrystalline Cellulose (MCC) MSDS 1. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Page 1 of 8. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. SDS. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Origin(s): Plant/Botanical. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. Protect them from sunshine or rain. The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. This Microcrystalline Cellulose . Synonyms: Cellulose, Cellulose powder, Cotton linters. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. >> It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. It is hygroscopic and insoluble in water. % The data shown below apply only to Avicel PH 101. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). These grades have particle sizes ranging from <30 to approximately 200. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. common form is used in vitamin supplements or tablets. pH 6.0 to 8.0 . Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. JFIF ` ` ZExif MM * J Q Q Q C F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Home. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. The aqueous solution to barrier membrane coating. ( )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? <> Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; endobj You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. FMC, JRS and Mingtai were estimated to hold for . However, it yields non-digestible fibre. Validity Area. q86@on$^X_HuH;3` Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. POLYOX resins are nonionic polyethylene oxide solubility polymers. Production of Pharmaceutical Grade Microcrystalline Cellulose. <> It works as a moisture sponge and permits the controlled growth of spheroids. Quick Links. AVICEL RC 581. stream An agricultural sciences company. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. (&E. PDF (28.38 mb) 2022 Corporate Fact Sheet. All Rights Reserved. EMCOCEL XLM 90. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. w !1AQaq"2B #3Rbr Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. EMCOCEL 90 M. 130. FMC Corporation. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? We know that our customers need to provide reliable and consistent products to their patients. Within the pharmaceuticals field, where the bulk of this material is utilised, Avicel Microcrystalline cellulose functions as a filler and diluent, dry binder, flow, disintegrating, and compression aid in tablets, capsules, and granules. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Alginates also function as actives in some anti-reflux products. X\o^ Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Avicel PH-101. PharmaCentral 2021 . [FMC Study Number I92-1464]. By producing Avicel . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. ). Created Date: 2/10/2020 8:51:41 PM . Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . 1. SDS - Safety Data Sheet. Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. /Parent 3 0 R stream ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" MATERIAL SAFETY DATA SHEET Version: 1.0 1. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Product Name Cellulose microcrystalline. These, in turn, are assembled into fibrils in the cell wall. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? endobj XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? The most. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Trademarks: Avicel PH-102. 5 0 obj Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Explore how we work and why we apply science and creativity for a better world to everything we do. Instead, they obtained a stable colloidal suspension. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . It is . It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. Go to Investor Relations. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. We are artists at heart and creators by nature. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe The cellulose molecule is formed through repeated condensation of cellobiose units. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. stream CAS 9004-34-6. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals. Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. Buy Chemicals. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. Request media, explore upcoming events and read our latest updates. Some substance identifiers may have been claimed confidential, or may . MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. % lH5JWy}DgKRR"Fs 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Catalog Number 102331. There have always been two different points of view for the liquidity of MCC. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. ChemicalBook. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. However, consumption of large quantities of the material may have a laxative effect. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. A., and Smith, P. A. . ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Earth Supplied Products LLC. The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. %PDF-1.5 If breathing is difficult or if . Microcrystalline Cellulose / Avicel PH-102. No. . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Unique functionality for a broad range of pharmaceutical applications. Medium size standard MCC grade, suited for the majority of directly compressible actives. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Revision No. : 5. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Heavy metals, % NMT 0.001 Superior Performance: Provides excellent water uptake and rapid swelling . HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder.