sheng lab broad institute

Postdoctoral Associate - Sheng Lab Cambridge, MA $47K - $89K ( Glassdoor est.) Epub 2017 Dec 1. Review. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. The repertoire of naturally occurring proteins is limited and many molecules induce multiple conflicting effects. The four magnified images on the right show how the cell takes up the treatment across a span of 30 seconds. As Co-Director of the Stanley Center, Sheng will work with Stanley Center Director Steven Hyman to shape the centers scientific vision and direction, in addition to overseeing the centers therapeutic efforts, in conjunction with the Broads Center for the Development of Therapeutics. NE30-6031. Compositions and Methods for Conversion of Aldehydes to Alkanes (2011) Weiqing Zeng and Sheng Yang He. . Mailing address: California Institute of Technology. Following postdoctoral research in the lab of Lily Jan at the University of California, San Francisco, Sheng served as a faculty member in the Department of Neurobiology . From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. By the end of 2022, Broads COVID-19 testing lab had processed more than 37 million tests. 1 Broad Institute of MIT and . Journal of Biological Chemistry 277 (8), 5699-5702, 2002. Chan School of Public Health to study the genetics of severe mental illness, has recruited more than 42,000 participants in Ethiopia, Kenya, Uganda, and South Africa. He is also a professor of neuroscience in MIT's Department of Brain and Cognitive Sciences, and an . Our research is mainly focused on the RNA chemical modification and RNA structure biology. In March of 2020, Broad Institute converted a clinical genetics processing lab into a large-scale COVID-19 testing facility in less than two weeks. Prof. Gong's research group focuses on the design, synthesis/fabrication, and characterization of novel materials and devices. 415 Main St. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. Published in NANO Letters, the study was led by Zhi Sheng and Deborah . Working with Addgene, Broad Institute has shared CRISPR genome-editing reagents with researchers at more than 3,200 institutions in 76 countries. Meet our members, staff scientists, fellows and other Broadies. A multimodal molecular cell-type atlas of the MOp. Shawn has a broad range of experience: mechanical and electrical system modeling and analysis; data sensing and sensor placement; signal processing; machine learning and artificial intelligence; machine defect classification and level evaluation; machine life prognosis; multi scale modeling; traditional and . Lawrence Berkeley National Laboratory (LBNL), commonly referred to as the Berkeley Lab, is a United States national laboratory owned by, and conducting scientific research on behalf of, the United States Department of Energy.Located in the hills of Berkeley, California, the lab overlooks the campus of the University of California, Berkeley, and is managed by the University of California system. This researcher will work in close collaboration with laboratory scientists on analysis of a range of projects with a strong emphasis on bulk RNA-seq and single cell approaches. Important new look into the Alzheimer's brain from a collaboration including Morgan Sheng, a Picower Institute affiliate professor based at . Featuring speakers from the Nedivi, Littleton, and Sur labs. The Stanley Center aims to reduce the burden of serious mental illness by contributing new insights into pathogenesis, identifying biomarkers, and paving the way toward new treatments. Postdoctoral Associate - Sheng Lab in The Broad Institute, Inc. Cambridge, MA. In collaboration with labs at ADARC, we sequence viral antigen-specific B cell receptors (BCRs) to identify immune signatures of infections including . Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. Associate Investigator, Broad Institute of Harvard/MIT Investigator, HHMI. M Sheng, S Smiga, A Bulfone, . Eunah Yu received her PhD in Neuroscience from Seoul National University. Broad Institute. 699 Bradley C. Paasch, Reza Sohrabi, Kinya Nomura & Sheng Yang He 700 701 . The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The mission of the Stanley Center is to improve the lives of patients suffering from serious mental illnesses, through groundbreaking basic and translational . Lab studies the genetics underlying neural development to identify new diagnostic and therapeutic approaches for a broad range of disorders that compromise brain and organ system development. He is also. This center is developing new paradigms and technologies to scale the discovery of biological mechanisms of common, complex diseases, by facilitating close collaborations between the Broad Institute and the Danish research community. Email. All Rights Reserved. 10 The Xpert test has shown both accurate performance in . The Stanley Center has gained unprecedented insight into the genetic basis of psychiatric illness (schizophrenia, bipolar disorder, autism). Fralin Biomedical Research Institute faculty conduct research in wet and dry labs in our 280,000-square-foot facilities . Affiliations 1 State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. See popular questions & answers about Broad Institute; Post-Doctoral Associate - Neuroscience Department. Sheng J, Gan, J, Soares, A, Salon, J, Huang Z. He has served on the editorial boards of Neuron, Journal of Neuroscience, and Current Opinions in Neurobiology. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broad's Stanley Center for Psychiatric Research. Sheng Lin-Gibson is the chief of the Biosystems and Biomaterials Division at the National Institute of Standards and Technology (NIST). Sheng is a fellow of the Royal Society (UK), a fellow of the Academy of Medical Sciences (UK), a fellow of the American Association for the Advancement of Science, and honorary fellow of Corpus Christi College, Oxford. 30 The Broad Institute Postdoctoral Chemistry jobs in Us. Professor, Department of Otolaryngology - Head and Neck Surgery; . . Every summer, 18 high school students spend six weeks at Broad working side-by-side with mentors on cutting-edge research. We are a team of scientists studying the genetic basis and molecular mechanisms underlying schizophrenia and other brain disorders. Category: research Scientists at Fralin Biomedical Research Institute develop new strategy for brain cancer treatment. He joined Cornell University in 2003 where he is currently the William L. Lewis Professor of Engineering in the Robert F. Smith School of Chemical and Biomolecular . Cambridge, MA 02142. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. 688 Timothy Johnson and lab technician David Rhodes for assistance in gnotobiotic system . Shawn has a broad range of experience: mechanical and electrical system modeling and analysis; data sensing and sensor placement; signal processing; machine learning and artificial intelligence; machine defect classification and level evaluation; machine life prognosis; multi scale modeling; traditional and . Dr. Sheng Ding is currently William K. Bowes, Jr. Combining cutting-edge technologies from structural biophysics, molecular engineering, and translational . A physician and a scientist, Morgan Sheng is author of more than 200 peer-reviewed publications focused on the molecular cellular biology of synapses and synaptic plasticity, and pathogenic mechanisms of neurodegenerative diseases. Our researchers use their expertise in creating, adapting, and applying a variety of technologies to enable science here and beyond. Merkin Building biology .mit .edu. Following postdoctoral research in the lab of Lily Jan at the University of California, San Francisco, Sheng served as a faculty member in the Department of Neurobiology at Massachusetts General Hospital and Harvard Medical School (1994-2001) before joining MIT (2001-2008). in chemistry with honors from Caltech in 1999, and a . Distinguished Investigator and Professor at Gladstone Institute of Cardiovascular Disease, and Department of Pharmaceutical Chemistry, University of California San Francisco. 2018 Dec 19;100(6):1322-1336.e7. Read . The McGovern Institute is an integral part of MIT with a board that includes representatives appointed by the McGovern family and by MIT. Learn about Broad Institute's mentored research offerings for high school students, college students, and recent college graduates. . LinkedIn profile Based on the above information, the Hydrus-2D model was established, then the study area was Jo ur na l P re -p ro of Journal Pre-proof 12 discretized and . Work with wet-lab biologists to design and implement appropriate experiments for future computational analysis in areas such as neurophysiology and behavior. In this paper, the effects of ultrasound frequency (17-25 kHz), power . Morgan Sheng, a neurobiologist and physician-scientist with deep experience in both basic research and drug discovery, has joined the Broad Institute of MIT and Harvard as its newest Core Member and as Co-Director of the institute's Stanley Center for Psychiatric Research. Dr. Sheng was elected to AAAS Fellow in 2016 and ASCB fellow in 2017 for his contributions to the field of axonal transport of mitochondriaand endolysosomes in maintenance of neuronal homeostasis and synaptic function in health and diseases. Nature neuroscience 12 (4), 428-437, 2009. . Dr. Sheng Ding is currently William K. Bowes, Jr. More than 11,000 individuals living with cancer in the United States and Canada have partnered with Count Me In to share their experiences and help accelerate cancer research. Copyright 2008-2023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc, The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the. In Situ Biology . He has used a broad range of approaches to tackle these problems, notably the development of neuronal cultures from adult disease . Institute Member, Broad Institute of MIT and Harvard Office: 46-3143A / Phone: (617) 715-4898 . This candidate will collaborate with biologists and geneticists to perform various analysis including transcriptomics and proteomics analysis, pathway analysis and biological interpretations. In Situ Biology Join Us Contact The Chen Lab. Job Description. I am currently an Associate Computational Biologist II in the Morgan Sheng lab at the Broad Institute of MIT and Harvard. The Broad faculty consists of Institute Members and Associate Members. School of Environment, Harbin Institute of Technology, Harbin, 150090, P. R. China . 46-1303 Cambridge, MA 02139 . He was first trained as a molecular biologist in the University of Hong Kong Sean Moran is a neuropharmacologist with a strong passion for translational neuroscience research who earned his PhD from Vanderbilt University under the mentorship of P. Jeffrey Conn. During his Lei is an interdisciplinary scientist with skills in neuroscience, machine learning, and software development. We work closely with pharmaceutical, biotech, and technology partners to accelerate the translation of our discoveries. Faculty Assistant Mary Gidaro mgidaro@princeton.edu 105 Thomas Laboratory p 609-258-8956 f 609-258-1704. Identified telomerase isoforms by integrating NGS and RACE data: Designed and performed experiments (RACE) and sequence analyses (bash). The Xpert HIV-1 qualitative assay (Xpert HIV-1 Qual; Cepheid, Sunnyvale, CA, USA) for early infant diagnosis is considered to be a point-of-care test according to the REASSURED criteria; 9 although it takes 90 min, the assay is able to provide results on the same day as testing. Hansen DV, Hanson JE, Sheng M. J Cell Biol. Visit our free public educational space that showcases how researchers at the Broad and their colleagues around the world seek to understand and treat human disease. My research will involve a combination of organic synthesis, microbiology, molecular biology, enzymology, and potential optimization of . The address is No. In 1990, he earned his Ph.D. in molecular genetics from Harvard University and completed his postdoctoral fellowship at the University of California, San Francisco. Software Engineer. US 5849868 A Epub 2018 Nov 1. He has served on the editorial boards of, Presidential Early Career Award for Scientists and Engineers, Young Investigator Award, Society for Neuroscience (1999), President, Society of Chinese Neuroscientists of America (2001-2003), Fellow of the American Association for the Advancement of Science (AAAS) (elected Sept 2004). Sheng J, Zhang W, Hassan A, Gan J, Soares A, Geng S, Ren Y, Huang Z. Hydrogen Bond Formation between the Naturally Modified Nucleobase and Phosphate Backbone. From 2008 to 2019, Sheng was vice-president of neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. The Stanley Center engages in large-scale, globally conducted studies of . Job Description The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The mission of the Stanley Center is to improve the lives of patients suffering from serious mental illnesses, through groundbreaking basic and translational research. In a new study published in Oncogenesis, Zhi Sheng and Rob Gourdie of the Fralin Biomedical Research Institute at VTC describe how two protein-targeting drugs - when combined with chemotherapy - yield synergistic cytotoxicity to treatment-resistant glioblastoma. Mackenzie Abbott. 11:45 - 12:45 LUNCH & VIRTUAL SOCIALS Kate Mulherin. Should have a demonstrated proficiency in R and/or Python, or related languages, Experience with and solid understanding of statistical analysis is required, Familiarity with next-generation sequence data analysis tools and packages, particularly those for bulk and single cell/nucleus RNA-seq, Understanding of molecular biology and next generation sequencing is highly preferred, Familiarity with working on a computing cluster/server (important skills: Unix/Linux, shell scripting). The impact of Shengs research has been recognized by several prizes including the Fondation IPSEN Prize for Neuronal Plasticity and the Society for Neurosciences Young Investigator Award. The observed reaction rate is . His work has uncovered the form and complexity of protein complexes in the postsynaptic membrane that regulate the remarkable plasticity of neuronal connections. Queen's University. Fusarium wilt of banana, especially Tropical Race 4 (TR4) is a major factor restricting banana production. Avoid inappropriate use of antibacterial drugs, especially the combined use of broad-spectrum antibacterial drugs. Merkin Building Meet our members, staff scientists, fellows and other Broadies. The successful candidate will join a multidisciplinary group and perform cutting-edge basic and/or translational research on the molecular, cellular and neurobiological mechanisms of psychiatric disorders, especially in relation to risk genes for schizophrenia and bipolar disorder, synapse development/elimination, synaptic function/plasticity, neuron-glia interactions, and neural circuitry/interneurons. Broad Institute 4.0. . The EWSC is catalyzing a new field of interdisciplinary research at the intersection of data science and life science, aimed at improving human health. Job Description. the broad institute of mit & harvard is looking for outstanding postdoctoral scholars to join the laboratory of morgan sheng, co-director of the stanley center for psychiatric research, the mission. Popular Locations. Ringel, Alison E. . Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. Neuron 2016 Jul 20;91(2):328-40. As the Director for Translational Neurobiology at Stanley Center, Dr. Pan aspires to translate the understanding of the genetics and biology of psychiatric and neurological illnesses to novel therapeutics for severe mental illnesses. Dr. Sheng received the 2021 Dr. Francisco S. Sy Award for Excellence in Mentorship at HHS. Fei was a Schmidt Fellow at the Broad Institute from 2017-2020. Nov 2014 - Jun 20158 months. The mechanisms of chemical reactions, including the transformation pathways of the electronic and geometric structures of molecules, are crucial for comprehending the essence and developing new chemistry. Dr. Sheng has also servedon the editorial board of Journal of Cell Biology (JCB) and Journal of Biological Chemistry (JBC) and associate editor of Autophagy. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. 46-5285. . Postdoctoral Associate - Sheng Lab Broad Institute of MIT and Harvard Cambridge, MA 1 month ago Be among the first 25 applicants Director, Cornell Institute of BiotechnologyDirector, Center for Life Science Enterprise. Shengs molecular studies of the structure and function of synapses (the communication junctions between brain cells) while at MGH and MIT have enhanced our understanding of the neural basis of cognitive function and dysfunction, including learning and memory, neurodevelopmental disorders, and dementia. in chemistry with honors from Caltech in 1999, and a Ph.D. in chemistry from The Scripps Research . Neurobiologist and drug developer returns to academia to help guide the Broads psychiatric research. Many members of the faculty hold joint appointments with other departments at MIT and with outside institutions. See Adata Technology 's products and customers Thousands of companies like you use Panjiva to research suppliers and competitors. BS (with 1-3 years of experience) or MS (with 0-2 years of experience) in Bioinformatics, Computer Science, or other relevant scientific discipline or equivalent experience is required. Our community is deeply engaged in the local, national, and global effort to respond to COVID-19. Morgan Sheng is a core institute member of the Broad Institute of MIT and Harvard, where he serves as co-director of the Broads Stanley Center for Psychiatric Research. 69, Lide St. Zhonghe Dist., New Taipei City, TW. The Broad Institute of MIT & Harvard is looking for outstanding postdoctoral scholars to join the laboratory of Morgan Sheng, Co-Director of the Stanley Center for Psychiatric Research, The . Washington, DC; Chicago, IL; New York, NY; San Francisco, CA; Dallas, TX; Search. He is also a professor of neuroscience in MITs Department of Brain and Cognitive Sciences, and an affiliate of both the McGovern Institute for Brain Research and the Picower Institute for Learning and Memory. In November 2022, Broads Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. Sheng-Yong NIU | Cited by 405 | of Broad Institute of MIT and Harvard, MA | Read 19 publications | Contact Sheng-Yong NIU From 2008 to 2019, Sheng was Vice-President of Neuroscience at Genentech, a leading biotech company, where he led research and drug discovery efforts for major diseases of the nervous system. Broad-spectrum disease resistance conferred by expression of the Pseudomonas syringae hrmA gene in plants (2001) Qingshun Li, Songhai Shen, Arthur Hunt and Sheng Yang He. In the past few years, Pan has been working on genes whose dysfunction has been implicated for psychiatric illnesses using molecular, cellular, and electrophysiological approaches, both in vitro and in animals. Sign in to create your job alert for Research Scientist jobs in United States. Research Areas . Learn about breakthroughs from Broad scientists. Feng Laboratory McGovern Institute For Brain Research 43 Vassar Street, Office: 46-3133 Cambridge, Massachusetts 02139 Phone: (617) 715-4920 Website: fenglaboratory.org. Some of their efforts include multifunctional drug/agent nanocarriers for the . His Ph.D. thesis was completed at Harvard Medical School in the lab of Michael Greenberg. Broad Institute of MIT and Harvard; Simons Center for the Social Brain; Massachusetts Institute of Technology Research. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on Resuscitation, European Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation . Dr. Pan has more than 15 years of experience investigating the function, molecular genetics and pharmacology of ion channels. From 2001 to 2008, Sheng was the Menicon Professor of Neuroscience at MIT, as well as an investigator of the Howard Hughes Medical Institute. A past recipient of the Fondation Ipsen Prize in Neuronal Plasticity and the Young Investigator Award of the Society for Neuroscience. This job is no longer available, but here are similar jobs you might like. Minneapolis, MN +1 location. Dr. Sheng received his Ph.D. in Biochemistry from the University of Pennsylvania in 1993. Howard Hughes Medical Institute, Duke University, Durham, NC, USA . Find your next job opportunity near you & 1-Click Apply! 908: Structural Insights of Non-canonical U-U Pair and Hoogsteen Interaction Probed with Se Atom. Yang uses biochemical and Lei is a postdoctoral researcher in the Pan Group at the Stanley Center for Psychiatric Research. As Co-Director of the Stanley Center for Psychiatric Research at the Broad Institute, Sheng will help to shape the center's scientific vision and direction, and oversee the center's efforts to develop therapeutics for schizophrenia and other serious mental illnesses. At Genentech he built and led a world-class neuroscience department and research program focused on elucidating pathologic mechanisms and developing new treatments for neurodegenerative diseases and pain, and illuminating pathways that are of basic scientific interest as well as therapeutic relevance. This study aimed to uncover and analyze the mitophagy-related diagnostic biomarkers in HCC using . We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). In November 2022, Broads Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. We seek to understand how lipid macromolecules are generated, stored, and metabolized, and how lipid processes function in membrane biology and cell physiology. These new phases exhibit huge unit cells (V . She leads the ICE-T (ion channel electrophysiology and technology) effort enabled by Broadnext10 initiative to utilize state-of-art technologies for studying ion channels and electrogenic transporters, and to find novel ways to modulate these highly specialized membrane proteins. Email. POSTED ON 12/18/2022 AVAILABLE BEFORE 5/17/2023. Please contact Prof. Sheng-Yang He (shengyang.he@duke.edu; hes@msu.edu). All Broad employees, regardless of work location, must be fully vaccinated for COVID-19 by Tuesday, October 12, 2021. Through Broad's Scientists in the Classroom program, Broad researchers visit every 8th grade classroom in Cambridge each year to talk about genetics and evolution. Broad Institute 4.0. Frequently searched careers. Morgans groundbreaking research has accelerated the understanding of brain synapses in health and disease, said Eric Lander. Broad brings people together to advance the understanding and treatment of disease. Oana Ursu Status: Postdoc, Aviv Regev lab, Broad Institute Lab Affiliation: PhD, Genetics Dept., Co-advised by Mike Snyder Sept 2013 - Mar 2018 (HHMI International Fellow) Research focus: 3D genome organization, enhancer-gene linking, regulatory . He completed his postdoctoral research with William Catterall at the University of Washington in 1996. Lei received his PhD in Neuroscience under the doctoral program of "Molecular Physiology of the Brain" Nikita completed his Cognitive Science Bachelor's degree from McGill university in the spring of 2019 focusing in the fields of Neuroscience and Philosophy. Affiliated Research Lab Inner Ear Electrophysiology Laboratory; Academic profile. $115,000.00, $130,000.00 A catalog of scientific papers published by our members and staff scientists. The Eli and Edythe L. Broad Institute of MIT and Harvard (IPA: / b r o d /, pronunciation respelling: BROHD), often referred to as the Broad Institute, is a biomedical and genomic research center located in Cambridge, Massachusetts, United States.The institute is independently governed and supported as a 501(c)(3) nonprofit research organization under the name Broad Institute Inc., and it .